ABSTRACT
Objective To explore the three ultrasonic technologies of two -dimensional ultrasound(2D -US),ultrasonic elastography(UE) and contrast -enhanced ultrasound(CEUS) for the measurement error in breast cancer and the correlation with the expression of ER,PR,VEGF.Methods 50 patients with breast cancer were meas-ured by 2D -US,UE,CEUS preoperatively,and the pathological specimen were measured postoperatively.Then used the immunohistochemistry to detect the expression of ER,PR,VEGF in tumor,and analyzed the correlation with the measurement errors.Results The results of differences between 2D -US,UE,CEUS and pathology were respectively as follows:( -0.59 ±-0.34)cm,( -0.20 ±-0.14)cm,( -0.40 ±-0.31)cm,and the differences were statistically significant(F =20.497,P <0.001).The positive expression rate of ER and PR was high if the difference between UE and 2D -US was less than or equal to 0.44cm.And the positive expression rate of VEGF was low if the difference between CEUS and 2D -US was less than or equal to 0.19cm.Three ultrasonic technologies in the measurement of breast cancer were different,the trend of difference between UE and 2D -US was smaller if the ER and PR were positively expression,and the trend of difference between CEUS and 2D -US was bigger if the VEGF was positively expression.Conclusion There is correlation between different immunohistochemical expression of breast cancer with measurement error in three different ultrasonic imaging technologies.The results suggest that the molecular pathology difference of breast cancer can impact on ultrasonic imaging,which contributes to know the reason and regulation of measurement error in different ultrasonic imaging technology.
ABSTRACT
<p><b>OBJECTIVE</b>To make a study of the clinical effect on the treatment of chronic obstructive pulmonary disease in acute aggravated stage with Tanreqing Injection and the changes of the cell factor level.</p><p><b>METHOD</b>Eighty-seven cases of COPD patients in acute aggravated stage were chosen and divided into two groups at random. Forty-four cases in treatment group were given intravenous drip of Tanreqing (20 mL) with 5% G/NS (500 mL) once a day. Forty-three cases in control group were given intravenous drip Yanhuning injection (0.4 g) with 5% G/NS (500 mL) once a day. The courses of the treatment were both two weeks and the changes of TL-10, TNF-alpha and MPO were observed separately before and after the treatment.</p><p><b>RESULT</b>The total effective rate in the treatment group was 94.31% while the control group 83.75%, which had significant difference (P<0.05). IL-10 level in both groups was comparatively lower than the healthy (P<0.01), while TNF-alpha and MPO was higher than the healthy (P<0.01). After the treatment, the TNF-alpha and MPO level in the treatment group decreased more greatly than those in the control groups (P<0.01) but the IL-10 increased a lot more than those in the control group and there existed remarkable difference (P<0.01).</p><p><b>CONCLUSION</b>The treatment of chronic obstructive pulmonary disease in acute aggravated stage with Tanreqing Injection can have noticeable effect, and can prohibit the release of above cell factors. It is also safe in clinical use without obvious side effects and has played an important role in the treatment of chronic obstructive pulmonary disease in acute aggravated stage.</p>
Subject(s)
Adult , Aged , Female , Humans , Male , Middle Aged , Cytokines , Blood , Drug-Related Side Effects and Adverse Reactions , Drugs, Chinese Herbal , Therapeutic Uses , Injections , Interleukin-10 , Blood , Peroxidase , Blood , Pulmonary Disease, Chronic Obstructive , Blood , Drug Therapy , Therapeutics , Treatment Outcome , Tumor Necrosis Factor-alpha , BloodABSTRACT
Objective To investigate the effect of age on activity of cholineacetyltransferase(ChAT) and acetylcholinesterase(AChE) in cerebral cholinergic nerve system of rat.Method According to age,male Sprague-Dawley rats were divided into the following 3 groups at random: 4～5 weeks old group,4～5 months old group,14～15 months old group(n=10,respectively).Chromatometry was used to assay the activity of ChAT and AChE in cerebral cortex,hippocampus and corpus striatum.Results In 14～15 months old rats,activity of ChAT and AChE in cerebral cortex,hippocampus and corpus striatum was prominantly reduced,as compared with that in 4～5 months old rats and in 4～5 weeks old rats(ChAT: P0.05).Conclusion There is a negative correlation between age and activity of ChAT and AChE in cerebral cholinergic nerve system.